Научные статьи на тему диагностики аллергии с использованием ISAC чипа

  • 2014

  • 2013

    A WAO - ARIA - GA2LEN consensus document on molecular-based allergy diagnostics.
    Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, Melioli G, Nunes C, Passalacqua G, Rosenwasser L, Sampson H, Sastre J, Bousquet J, Zuberbier T, Allen K, Asero R, Bohle B, Cox L, de Blay F, Ebisawa M, Maximiliano-Gómez R, González-Diaz S, Haahtela T, Holgate S, Jakob T, Larché M, Maria Matricardi P, Oppenheimer J, Poulsen LK, Renz HE, Rosário N, Rothenberg M, Sanchez-Borges M, Scala E, Valenta R.
    World Allergy Organization Journal 2013, 6:17. doi:10.1186/1939-4551-6-17, Published: 3 October 2013

    Der Allergenchip im klinischen Alltag (PDF).
    Mothes-Luksch N.
    Jatros Dermatologie und Plastische Chirurgie, 2013 (2): 10-12.
    Comment: AllergyCare-Publikation.

    Measurement of IgE to pollen allergen components is helpful in selecting patients for immunotherapy.
    Letrán A, Espinazo M, Moreno F.
    Ann Allergy Asthma Immunol xxx (2013) 1e3

    The additional values of microarray allergen assay in the management of polysensitized patients with respiratory allergy.
    Passalacqua G, Melioli G, Bonifazi F, Bonini S, Maggi E, Senna G, Triggiani M, Nettis E, Rossi RE, Vacca A, Canonica GW; Italian ISAC Study Group.
    Allergy. 2013 Aug;68(8):1029-33. doi: 10.1111/all.12194. Epub 2013 Jul 29.

    Molecular microarray analysis reveals allergen- and exotoxin-specific IgE repertoires in children with atopic dermatitis. Ott H, Weißmantel S, Kennes LN, Merk HF, Baron JM, Fölster-Holst R.
    J Eur Acad Dermatol Venereol. 2013 Jan 10. doi: 10.1111/jdv.12083. [Epub ahead of print]

    Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg.
    Meglio P, Giampietro PG, Carello R, Gabriele I, Avitabile S, Galli E.
    Pediatr Allergy Immunol. 2013 Feb;24(1):75-83. doi: 10.1111/j.1399-3038.2012.01341.x. Epub 2012 Aug 13.

    Isolated IgE reactivity to native walnut vicilin-like protein (nJug r 2) on ISAC™ microarray is due to cross-reactive carbohydrate epitopes.
    Villalta D, Conte M, Asero R, Da Re M, Stella S, Martelli P.
    Clin Chem Lab Med. 2013 Mar 26:1-5. doi: 10.1515/cclm-2013-0027. [Epub ahead of print] Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy.
    Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek T, Lang R.
    Int Arch Allergy Immunol. 2013;161(3):229-33. doi: 10.1159/000345970. Epub 2013 Mar 15. PMID: 23548307 [PubMed - in process]
  • 2012

    The IgE repertoire in children and adolescents resolved at component level: A cross-sectional study.
    Melioli G, Marcomini L, Agazzi A, Bazurro G, Tosca M, Rossi GA, Minale P, Rossi R, Reggiardo G, Canonica GW, Passalacqua G.
    Pediatr Allergy Immunol. 2012 Aug;23(5):433-40.
    Comment: ISAC analysis of 901 patients (0-65 years of age), where age dependent patterns of sIgE towards different families of allergen components are nicely demonstrated.

    Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults.
    Lupinek C, Marth K, Niederberger V, Valenta R.
    J Allergy Clin Immunol. 2012 Aug 3. [Epub ahead of print]

    Peanut seed storage proteins are responsible for clinical reactivity in Spanish peanut-allergic children.
    Pedrosa M, Boyano-Martínez T, García-Ara MC, Caballero T, Quirce S.
    Pediatr Allergy Immunol. 2012 Jul 26. [Epub ahead of print]

    Age-dependent sensitization to the 7s-vicilin-like protein cor a 11 from hazelnut (corylus avellana) in a birch-endemic region
    Verweij M.M., Hagendorens M.M., Trashin S., Cucu T., de Meulenaer B. Devreese B., Bridts C., de Clerck L.S., Ebo D.G.
    J. Invest. Allergol. Clin. Immunol. 2012 22:4 (245-251)

    Microarray-based detection of specific IgE against recombinant ω-5-gliadin in suspected wheat-dependent exercise-induced anaphylaxis.
    Brans R, Sauer I, Czaja K, Pfützner W, Merk HF.
    Eur J Dermatol. 2012 May-Jun;22(3):358-62.

    The added value of allergen microarray technique to the management of poly-sensitized allergic patients.
    Melioli G, Compalati E, Bonini S, Canonica GW.
    Curr Opin Allergy Clin Immunol. 2012 May 22. [Epub ahead of print]

    Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness.
    Patelis A, Gunnbjörnsdottir M, Malinovschi A, Matsson P, Onell A, Högman M, et al J Allergy Clin Immunol. 2012 May 25. [Epub ahead of print]

    Carrier-bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternata allergy
    T. E. Twaroch, M. Focke, K. Fleischmann, N. Balic, C. Lupinek, K. Blatt, et al and R. Valenta
    Clin Exp All 2012; 42(6):966–975.

    Molecular allergy diagnosis: we need to become more knowledgeable.
    Melioli G, Canonica GW.
    Ann Allergy Asthma Immunol. 2012 Jun;108(6):387.

    Microarray based IgE detection in poly-sensitized allergic patients with suspected food allergy —– an approach in four clinical cases
    Vieira T, Lopes C, Pereira AM, Araújo L, Moreira A, Delgado L.
    Allergol Immunopathol (Madr). 2012 May;40(3):172-80. Epub 2011 Jun 29.

    Secondary soy allergy in children with birch pollen allergy may cause both chronic and acute symptoms.
    De Swert LFA, Gadisseur R, Sjölander S, Raes M, Leus J, Van Hoeyveld E.
    Pediatr Allergy Immunol 2012; 23:117-123

    IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma
    B. Nordlund, J. R. Konradsen, I. Kull, M. P. Borres, A. Önell, G. Hedlin and H. Grönlund Allergy 2012; 67:661-669

    Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen's egg and an increased risk to progress to multiple environmental allergen sensitisation
    Alessandri C., Zennaro D., Scala E., Ferrara R., Bernardi M.L., Santoro M., Palazzo P., Mari A.
    Clin. Exp. Allergy 2012 42:3 (441-450)

    Note: Very useful paper!
    How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area
    Sastre J, Landivar ME, Ruiz-García M, Andregnette-Rosigno MV, Mahillo I.
    Allergy 2012; 67:709-711
    Comment: This study shows that the information provided with ImmunoCAP ISAC changed the SIT treatment in 54 % of the 141 patients included for SIT.

    Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen
    Shamji MH, Ljørring C, Francis JN, Calderon MA, Larche M, Kimber I, et al

    Cross-reactions vs co-sensitization evaluated by in silico motifs and in vitro IgE microarray testing
    Pfiffner P, Stadler BM, Rasi C, Scala E, Mari A.
    Allergy; 2012;67;2:210–216

    Beyond Skin Testing: State of the Art and New Horizons in Food Allergy Diagnostic Testing
    Caubet J-C , Sampson HA
    Immunol Allergy Clin North Am 2012;32;1:97-109

    Update on in vitro allergy diagnostics
    Treudler R
    J Dtsch Dermatol Ges. 2012 Jan 10
    Comment: Good review on components addressing the allergens both on ISAC and ImmunoCAP + some more.

    Proteomics plus genomics approaches in primary immunodeficiency: The case of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome
    Zennaro D., Scala E., Pomponi D., Caprini E., Arcelli D., Gambineri E., et al.
    Clin. Exp. Immunol. 2012;167:1;120-128
  • 2011

    Sensitization profiles in polysensitized patients from a restricted geographical area:
    Further lessons from multiplexed component resolved diagnosis
    Rossi RE, Melioli G, Monasterolo G, Harwanegg C, Rossi L, Canonica GW, Passalacqua G
    Eur. Ann. Allergy Clinical Immunol. 2011;43 (6),171-175

    Validation of immunoCAP ISAC assay performance
    Murng SHK, Egner W, Shrimpton A, Sargur R.
    Immunology 2011;135:73

    Molecular allergology in practice: An unusual case of LTP allergy
    Metz-Favre C., Pauli G., Bessot J.C., de Blay F.
    Eur. Ann. Allergy Clinical Immunol. 2011;43:6;193-195

    Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen’s egg and an increased risk to progress to multiple environmental allergen sensitisation
    Alessandri C., Zennaro D., Scala E., Ferrara R., Livia Bernardi M., Santoro M., Palazzo P. and Mari A.
    Clinical and Experimental Allergy 2011, Article first published online: 14 DEC 2011

    Birch-Apple Syndrome Treated with Birch Pollen Immunotherapy
    Mauro M, Russello M, Incorvaia C, Gazzola G, Frati F, Moingeon P, Passalacqua G
    Int Arch Allergy Immunol 2011;156:416–422

    Diagnosing latex sensitizations with recombinant latex allergens - the Immunosolid-phase allergen chip (ISAC)
    Seyfarth F, Schliemann S, WiegandC, Hipler U and Elsner P
    Exp. Dermatol. 2011 20:2 (163)

    Profilin: A relevant aeroallergen?
    Ruiz-García M, García del Potro M, Fernández-Nieto M, Barber D, Jimeno-Nogales L, Sastre J
    J Allergy Clin Immunol. 2011;128:2;1A-30A:255-436

    IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by allergen microarray-based technology
    Scala E, Alessandri C, Palazzo P, Pomponi D, Liso M, Bernardi ML, Ferrara R, Zennaro D, Santoro M, Rasi C, Mari A
    PLoS ONE 2011 6:9 Article Number e24912

    Specific IgE toward Allergenic Molecules Is a New Prognostic Marker in Patients with Sézary Syndrome
    Scala E, Abeni D, Palazzo P, Liso M, Pomponi D, Lombardo G, Picchio MC, Narducci MG, Russo G, Mari A
    Int Arch Allergy Immunol 2012;157:159-167

    The IgE-microarray testing in atopic dermatitis: a suitable modern tool for the immunological and clinical phenotyping of the disease
    Mari A, Scala E, Alessandri C
    Current Opinion in Allergy and Clinical Immunology 2011, 11:438–444

    [Microarray technique for component resolved diagnosis (CRD) in type-I allergies : An innovative technology at the border between research tool and routine diagnostics]. [Article in German]
    Klimek L, Vetter D, von Bernus L, Thorn C.
    HNO. 2011 Oct;59(10):988-93.

    A study of the variability of the in vitro component-based microarray ISAC CDR 103 technique.
    Cabrera-Freitag P., Goikoetxea M.J., Gamboa P.M., Martinez-Aranguren R., Beorlegui C. Fernandez J., Sanz M.L.
    J. Invest. Allergol. Clin. Immunol. 2011;21(5):414-415
    Sensitization profiles of a case of pollen-food allergy syndrome.
    Sano A, Yagami A, Inaba Y, Yamakita T, Suzuki K, Matsunaga K.
    Allergol Int. 2011 Mar;60(1):97-101.

    Anaphylaxis to Buckwheat in an Atopic Child: A Risk Factor for Severe Allergy to Nuts and Seeds?
    Varga EM, Kollmann D, Zach M, Bohle B.
    Int Arch Allergy Immunol. 2011 Mar 30;156(1):112-116.

    Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut.
    Schulten V, Nagl B, Scala E, Bernardi ML, Mari A, Ciardiello MA, Lauer I, Scheurer S, Briza P, Jürets A, Ferreira F, Jahn-Schmid B, Fischer GF, Bohle B.
    Allergy. 2011 Aug;66(8):1005-1013.

    Pollen-food syndrome is related to Bet v 1/PR-10 protein sensitisation, but not all patients have spring rhinitis
    Rashid RS, Smith KA, Nambiar KZ, Frew AJ, Tarzi MD.
    Allergy 2011 May 13. [Epub ahead of print]

    Use of allergen components begins a new era in pediatric allergology
    Borres MP, Ebisawa M, Eigenmann PA.
    Pediatric Allergy and Immunology 2011; 22; 454–461

    Can component-based microarray replace fluorescent enzimoimmunoassay in the diagnosis of grass and cypress pollen allergy?
    Cabrera-Freitag P, Goikoetxea MJ, Beorlegui C, Gamboa P, Gastaminza G, Fernández-Benítez M, Ferrer M, Blanca M, Sanz ML.
    Clinical & Experimental Allergy 2011 Jul 13, [Epub ahead of print]

    The ImmunoCAP ISAC molecular allergology approach in adult multi-sensitized Italian patients with respiratory symptoms.
    Melioli G, Bonifazi F, Bonini S, Maggi E, Mussap M, Passalacqua G, Rossi ER, Vacca A, Canonica GW; on behalf of the Italian Board for ISAC (IBI).
    Clin Biochem. 2011 Aug;44(12):1005-1011

    Microarray of allergenic component-based diagnosis in food allergy
    Maria L. Sanz, Ana B. Blázquez and Blanca E. Garcia
    Current Opinion in Allergy and Clinical Immunology 2011;11(3):204–209

    Component resolved diagnosis: Evolution or revolution in allergy diagnosis. (Les allergènes moléculaires évolution ou révolution dans le diagnostic de l'allergie) Bienvenua J, Rouzairea P, Bienvenua F.
    Revue Francaise d'Allergologie 2011;51(3):186-191

    Comparison of conventional and component resolved diagnostics by two different methods (Advia-Centaur/Microarray-ISAC) in pollen allergy
    Lizaso MT, García BE, Tabar AI, Lasa E, Echechipía S, Álvarez MJ, Anda M, Gómez B.
    Ann Allergy Asthma Immunol. 2011 Jul;107(1):35-41.

    Microarrayed recombinant allergens for diagnostic testing. Review article.
    Shreffler WG.
    J Allergy Clin Immunol. 2011;127(4):843-9

    A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP[1] 250 with the ImmunoCAP[1] ISAC
    Gadisseur R, Chapelle JP, Cavalier E.
    Clin Chem Lab Med 2011;49(2):277–280

    Component resolved diagnosis by the ISAC allergen microarray.
    Moneret-Vautrin DA
    Revue francaise d'allergologie. 2011

    Young infants with atopic dermatitis can display sensitization to Cor a 9, an 11S legumin-like seed-storage protein from hazelnut (Corylus avellana).
    Verweij MM, Hagendorens MM, De Knop KJ, Bridts CH, De Clerck LS, Stevens WJ, Ebo DG.
    Pediatr Allergy Immunol. 2011 Mar;22(2):196-201. [Epub ahead of print 2010]

    Age-related sensitization profiles for hazelnut (Corylus avellana) in a birch-endemic region.
    De Knop KJ, Verweij MM, Grimmelikhuijsen M, Philipse E, Hagendorens MM, Bridts CH, De Clerck LS, Stevens WJ, Ebo DG.
    Pediatr Allergy Immunol. 2011 Feb;22(1 Pt2):e139-49.

  • 2010

    Allergen microarrays: a novel tool for high-resolution IgE profiling in adults with atopic dermatitis.
    Ott H, Fölster-Holst R, Merk HF, Baron JM.
    European Journal of Dermatology, 2010 Jan-Feb;20(1):54-61.

    Gal d 6 Is the Second Allergen Characterized from Egg Yolk
    Amo A, Rodriguez-Pérez R, Blanco J, Villota J, Juste S, Moneo I, Caballero ML.
    J. Agric. Food Chem. 2010;58:7453–7457

    Recombinant Allergens. Routine diagnostics or still only science? (Translated from German)
    Schmid-Grendelmeier P.
    Der Hautarzt. 2010;November 61(11):946-953

    Molecular diagnosis in allergy.
    Sastre J.
    Clin Exp Allergy. 2010;40(10):1442-1460

    Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy.
    D'Urbano LE, Pellegrino K, Artesani MC, Donnanno S, Luciano R, Riccardi C, Tozzi AE, Ravà L, De Benedetti F, Cavagni G.
    Clin Exp Allergy. 2010;40(10):1561-1570

    Microarrays: Molecular allergology and nanotechnology for personalised medicine (II). Lucas JM.
    Allergol Immunopathol (Madr) 2010 Jul-Aug;38(4):217-23.

    Microarrayed allergen molecules for the diagnosis of allergic diseases.
    Mari A, Alessandri C, Bernardi ML, Ferrara R, Scala E, Zennaro D.
    Curr Allergy Asthma Rep. 2010 Sep;10(5):357-64.

    The importance of in vitro component-resolved diagnosis in paediatric patients.
    Goikoetxea MJ, Cabrera-Freitag P, Sanz ML, Fernández-Benítez M
    Allergol Immunopathol (Madr). 2010 Jan-Feb;38(1):37-40.

    Microarrays of Recombinant Hevea brasiliensis Proteins: A Novel Tool for the Component-Resolved Diagnosis of Natural Rubber Latex Allergy.
    Ott H, Schröder C, Raulf-Heimsoth M, Mahler V, Ocklenburg C, Merk HF, Baron JM.
    J Investig Allergol Clin Immunol. 2010;20(2):129-38.

    Component-resolved diagnosis of allergy: more is better?
    Salcedo G, Diaz-Perales A.
    Clinical and Experimental Allergy Editorial, Jun;40(6):836-8.

    Microarrays:Molecular allergology and nanotechnology for personalised medicine (I). Lucas JM.
    Allergol Immunopathol (Madr), 10 May-Jun;38(3):153-61.

    Cross-sectional survey on immunoglobulin E reactivity in 23 077 subjects using an allergenic molecule-based microarray detection system.
    Scala E, Alessandri C, Bernardi ML, Ferrara R, Palazzo P, Pomponi D, Quaratino D, Rasi C, Zaffiro A, Zennaro D, Mari A.
    Clinical and Experimental Allergy, 2010Jun;40(6):911-21.

    Component-resolved diagnosis from latex allergy by microarray.
    Ebo DG, Hagendorens MM, De Knop KJ, Verweij MM, Bridts CH, De Clerck LS, Stevens WJ.
    Clinical Experimental Allergy, 2010;10 Feb;40(2):348-58.

    Sensitization profiles in birch pollen-allergic patients with and without oral allergy syndrome to apple: lessons from multiplexed component-resolved allergy diagnosis.
    Ebo DG, Bridts CH, Verweij MM, De Knop KJ, Hagendorens MM, De Clerck LS, Stevens WJ.
    Clinical Experimental Allergy, 2010;Feb;40(2):339-47.

    Application of multiplexed immunoglobulin E determination on a chip in component-resolved diagnostics in allergy.
    Knol EF, Knulst AC.
    Clinical and Experimental Allergy, Editorial 2010 Feb;40(2):190-2.
  • 2009

    Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population.
    Krause S, Reese G, Randow S, Zennaro D, Quaratino D, Palazzo P, Ciardiello MA, Petersen A, Becker WM, Mari A.
    J Allergy Clin Immunol, 2009 Oct;124(4):771-8.e5.

    Molecular diagnosis in Allergology: application of the microarray technique.
    Ferrer M, Sanz ML, Sastre J, Bartra J, del Cuvillo A, Montoro J, Jáuregui I, Dávila I, Mullol J, Valero A.
    J Investig Allergol Clin Immunol, 2009;19 Suppl 1:19-24.
  • 2008

    Clinical usefulness of microarray-based IgE detection in children with suspected food allergy.
    Ott H, Baron JM, Heise R, Ocklenburg C, Stanzel S, Merk HF, Niggemann B, Beyer K.
    Allergy. 2008 Nov;63(11):1521-8.

    Component-resolved diagnosis in food allergy, are micro-array assays helpful to the clinician?
    Eigenmann, PA.
    Allergy, 2008; Nov;63(11):1519-20.
  • 2006

    Microarray-based IgE detection in capillary blood samples of patients with atopy.
    Ott H, Schröder CM, Stanzel S, Merk HF, Baron JM.
    Allergy. 2006 Sep;61(9):1146-7.

    Component-resolved diagnostics in food allergy.
    Lidholm J, Ballmer-Weber BK, Mari A, Vieths S.
    Current Opinion in Allergy and Clinical Immunology, 2006 Jun;6(3):234-40. Review.

    The performance of a component-based allergen-microarray in clinical practice.
    Wöhrl S, Vigl K, Zehetmayer S, Hiller R, Jarisch R, Prinz M, Stingl G, Kopp T.
    Allergy, 2006; May;61(5):633-9.
  • 2005

    Microarray-based IgE detection in capillary blood samples of patients with atopy.
    Ott H, Schröder CM, Stanzel S, Merk HF, Baron JM.
    Allergy. 2006 Sep;61(9):1146-7.

    Component-resolved diagnostics in food allergy.
    Lidholm J, Ballmer-Weber BK, Mari A, Vieths S.
    Current Opinion in Allergy and Clinical Immunology, 2006 Jun;6(3):234-40. Review.

    The performance of a component-based allergen-microarray in clinical practice.
    Wöhrl S, Vigl K, Zehetmayer S, Hiller R, Jarisch R, Prinz M, Stingl G, Kopp T.
    Allergy, 2006; May;61(5):633-9.
  • 2004

    Protein microarrays in diagnosing IgE-mediated diseases: spotting allergy at the molecular level.
    Harwanegg C, Hiller R.
    Expert Reviews in Molecular Diagnostics, 2004; Jul;4(4):539-48. Review.

    Microarrayed allergens for IgE profiling.
    Deinhofer K, Sevcik H, Balic N, Harwanegg C, Hiller R, Rumpold H, Mueller MW, Spitzauer S.
    Methods, 2004; Mar;32(3):249-54.
  • 2003

    Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E.
    Jahn-Schmid B, Harwanegg C, Hiller R, Bohle B, Ebner C, Scheiner O, Mueller MW.
    Clinical Experimental Allergy, 2003; Oct;33(10):1443-9.
  • 2002

    Microarrayed recombinant allergens for diagnosis of allergy.
    Harwanegg C, Laffer S, Hiller R, Mueller MW, Kraft D, Spitzauer S, Valenta R.
    Clinical Experimental Allergy, 2003; Jan;33(1):7-13. Review.

    Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment.
    Hiller et al.
    FASEB Journal, 2002; Mar;16(3):414-6.

Потому что ранняя


действительно важна.